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N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
| Product Name | N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide |
| Product Code | N00004729 |
| Chemical name | N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide |
| Synonyms | N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide; Abacavir - In House Impurity; Abacavir Impurities |
| Impurity | Abacavir - In House Impurity |
| CAS Number | 171887-03-9 |
| Alternate CAS # | |
| Molecular form | C₅H₄Cl₂N₄O |
| Appearance | Off-White to Pale Beige Solid |
| Melting Point | >251°C (dec.) |
| Mol. Weight | 207.02 |
| Storage | Amber Vial, Refrigerator, Under inert atmosphere |
| Solubility | DMSO, Methanol |
| Stability | |
| Category | Heterocycles, Nucleotides, Bases & Related Reagents |
| Boiling Point | |
| Applications | N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Dangerous Goods Info | |
| References | (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008) |
| Extra Notes | |
| Documents (MSDS) | No Data Available |
| Keywords | Buy 171887-03-9 | Purchase 171887-03-9 | Order 171887-03-9 | 171887-03-9 supplier | 171887-03-9 manufacturer | 171887-03-9 distributor | 171887-03-9 cost |
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