Product Name |
AdipoRon
|
Product Code |
A00003026
|
Chemical name |
AdipoRon
|
Synonyms |
2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide; 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
|
Impurity |
|
CAS Number |
924416-43-3
|
Alternate CAS # |
NA
|
Molecular form |
C₂₇H₂₈N₂O₃
|
Appearance |
White to Off-White Solid
|
Melting Point |
106-108°C
|
Mol. Weight |
428.52
|
Storage |
Refrigerator
|
Solubility |
Chloroform (Slightly), Methanol (Slightly)
|
Stability |
|
Category |
Agonist, Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
|
Boiling Point |
|
Applications |
AdipoRon is an AdipoR agonist and activates AMPK and PPAR-α pathways in the muscle and liver. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.
|
Dangerous Goods Info |
NA
|
References |
Okada-Iwabu, M., et. al.: Nature, 503, 493 (2013)
|
Extra Notes |
|
Documents (MSDS) |
No Data Available
|
Keywords |
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