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Ac-DEVD-AFC
| Product Name | Ac-DEVD-AFC |
| Product Code | A00002585 |
| Chemical name | Ac-DEVD-AFC |
| Synonyms | N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine; |
| Impurity | |
| CAS Number | 201608-14-2 |
| Alternate CAS # | NA |
| Molecular form | C₃₀H₃₄F₃N₅O₁₃ |
| Appearance | |
| Melting Point | |
| Mol. Weight | 729.61 |
| Storage | |
| Solubility | |
| Stability | |
| Category | |
| Boiling Point | |
| Applications | Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes’ shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3. |
| Dangerous Goods Info | NA |
| References | 1. Lazebnik, Y.A., et al. 1994. Nature. 371: 346-347. PMID: 8090205 2. Nicholson, D.W., et al. 1995. Nature 376: 37-43. PMID: 7596430 3. Xiang, J., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 14559-14563. PMID: 896209 4 .Chandler, J.M., et al. 1998. J. Biol. Chem. 273: 10815-10818. PMID: 9556551 5. Marcelli, M., et al. 1998. Cancer Res. 58: 76-83. PMID: 9426061 |
| Extra Notes | |
| Documents (MSDS) | No Data Available |
| Keywords | Buy 201608-14-2 | Purchase 201608-14-2 | Order 201608-14-2 | 201608-14-2 supplier | 201608-14-2 manufacturer | 201608-14-2 distributor | 201608-14-2 cost |
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