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Abacavir
| Product Name | Abacavir |
| Product Code | A000066 |
| Chemical name | Abacavir |
| Synonyms | (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; 1592U89; ABC; Abacavir API; Abacavir Impurities |
| Impurity | Abacavir API |
| CAS Number | 136470-78-5 |
| Alternate CAS # | NA |
| Molecular form | C₁₄H₁₈N₆O |
| Appearance | Off-White Solid |
| Melting Point | 94-97°C |
| Mol. Weight | 286.33 |
| Storage | Refrigerator |
| Solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| Stability | |
| Category | Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals |
| Boiling Point | |
| Applications | Abacavir (Abacavir API) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Dangerous Goods Info | NA |
| References | (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008) |
| Extra Notes | |
| Documents (MSDS) | Download Document |
| Keywords | Buy 136470-78-5 | Purchase 136470-78-5 | Order 136470-78-5 | 136470-78-5 supplier | 136470-78-5 manufacturer | 136470-78-5 distributor | 136470-78-5 cost |
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