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Abacavir-d4
| Product Name | Abacavir-d4 |
| Product Code | A000070 |
| Chemical name | Abacavir-d4 |
| Synonyms | (1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-methanol; 1592U89-d4; ABC-d4; Abacavir Stable Isotope |
| Impurity | |
| CAS Number | 1217731-56-0 |
| Alternate CAS # | 136470-78-5-unlabelled |
| Molecular form | C₁₄H₁₄D₄N₆O |
| Appearance | Off-White to Light Beige Solid |
| Melting Point | >70°C (dec.) |
| Mol. Weight | 290.36 |
| Storage | Hygroscopic, -20˚C Freezer, Under Inert Atmosphere |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Stability | Very Hygroscopic |
| Category | Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, |
| Boiling Point | |
| Applications | Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Dangerous Goods Info | NA |
| References | (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008) |
| Extra Notes | |
| Documents (MSDS) | Download Document |
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