Product Name |
AMG-458
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Product Code |
A00009400
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Chemical name |
AMG-458
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Synonyms |
1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; 2,3-Dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide;
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Impurity |
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CAS Number |
913376-83-7
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Alternate CAS # |
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Molecular form |
C₃₀H₂₉N₅O₅
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Appearance |
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Melting Point |
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Mol. Weight |
539.58
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Storage |
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Solubility |
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Stability |
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Category |
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Boiling Point |
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Applications |
AMG-458 is a potent inhibitor of c-Met with an IC50 of 60 nM.
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Dangerous Goods Info |
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References |
Liu, Longbin., et al.: J. Med. Chem., 51, 3688 (2008);
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Extra Notes |
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Documents (MSDS) |
No Data Available
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Keywords |
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