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6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

Product Name 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
Product Code A00007598
Chemical name 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
Synonyms 4-[4-[(2-Pyridyl)methoxy]-3-chloroanilino]-6-amino-3-cyano-7-ethoxyquinoline; 6-Amino-4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxyquinoline
Impurity
CAS Number 848139-69-6
Alternate CAS #
Molecular form C₂₄H₂₀ClN₅O₂
Appearance Off-White to Pale Yellow Solid
Melting Point 236-238°C (dec.)
Mol. Weight 445.9
Storage Refrigerator
Solubility Dichlomethane (Slightly), DMSO (Slightly)
Stability
Category Aromatic, Heterocycles, Amines, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point
Applications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.
Dangerous Goods Info
References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)
Extra Notes
Documents (MSDS) No Data Available
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6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
Product Packings
10mg
100mg
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