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1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one

Product Name 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one
Product Code O00002229
Chemical name 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one
Synonyms (5-O-Acetyl-β-D-ribofuranosyl)-Azacytidine;
Impurity
CAS Number 1174733-90-4
Alternate CAS # NA
Molecular form C₁₀H₁₄N₄O₆
Appearance White Solid
Melting Point >142°C (dec.)
Mol. Weight 286.24
Storage Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility DMSO (Slightly), Methanol (Slightly)
Stability Moisture sensitive
Category
Boiling Point
Applications 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one is an impurity of 5-Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.
Dangerous Goods Info NA
References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)
Extra Notes
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1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one
Product Packings
100mg
250mg
1g
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