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(1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol
| Product Name | (1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol |
| Product Code | R00006420 |
| Chemical name | (1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol |
| Synonyms | |
| Impurity | |
| CAS Number | 216481-88-8 |
| Alternate CAS # | |
| Molecular form | C₁₁H₁₂ClN₅O |
| Appearance | |
| Melting Point | |
| Mol. Weight | 265.7 |
| Storage | |
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| Boiling Point | |
| Applications | 1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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| References | |
| Extra Notes | |
| Documents (MSDS) | No Data Available |
| Keywords | Buy 216481-88-8 | Purchase 216481-88-8 | Order 216481-88-8 | 216481-88-8 supplier | 216481-88-8 manufacturer | 216481-88-8 distributor | 216481-88-8 cost |
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