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4-Amino-1-tert-butyl-3-(1’-naphthyl)pyrazolo[3,4-d]pyrimidine

Product Name 4-Amino-1-tert-butyl-3-(1’-naphthyl)pyrazolo[3,4-d]pyrimidine
Product Code A00007254
Chemical name 4-Amino-1-tert-butyl-3-(1’-naphthyl)pyrazolo[3,4-d]pyrimidine
Synonyms 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-NA-PP1;
Impurity
CAS Number 221243-82-9
Alternate CAS #
Molecular form C₁₉H₁₉N₅
Appearance White to Off-White Solid
Melting Point 215-218°C
Mol. Weight 317.39
Storage -20°C Freezer
Solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Stability
Category Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors,
Boiling Point
Applications A highly potent (IC50=1.5nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.
Dangerous Goods Info
References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005),
Extra Notes
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4-Amino-1-tert-butyl-3-(1’-naphthyl)pyrazolo[3,4-d]pyrimidine
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