4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
Product Name |
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
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Product Code |
A00007244
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Chemical name |
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
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Synonyms |
3-[(3-Bromophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-BrB-PP1;
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Impurity |
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CAS Number |
956025-99-3
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Alternate CAS # |
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Molecular form |
C₁₆H₁₈BrN₅
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Appearance |
Off-White to Pale Beige Solid
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Melting Point |
140-142°C
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Mol. Weight |
360.25
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Storage |
Refrigerator
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Solubility |
Chloroform (Slightly), Methanol (Slightly)
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Stability |
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Category |
Heterocycles, Nucleotides, Bases & Related Reagent, Protein Kinase Inhibitors and Activators
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Boiling Point |
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Applications |
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine is a small molecule Akt inhibitor. The kinase Akt is a key signaling node in regulating cellular growth and survival.
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Dangerous Goods Info |
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References |
Eblen, S., et al.: J. Biol. Chem., 278, 14926 (2003), Lindsley, C., et al.: Bioorg. Med. Chem. Lett., 15, 761 (2005), Manning, B., et al.: Cell, 129, 1261 (2007), Heerding, D., et al.: J. Med. Chem., 51, 5663 (2008),
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Extra Notes |
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Documents (MSDS) |
Download Document
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Keywords |
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