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(-)-Actinonin

Product Name (-)-Actinonin
Product Code A00002662
Chemical name (-)-Actinonin
Synonyms (2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide; Actinonine; 3-[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic Acid; Actinonin; CONA 57; Ro 06-1467;
Impurity
CAS Number 13434-13-4
Alternate CAS # NA
Molecular form C₁₉H₃₅N₃O₅
Appearance Off-White to Light Beige Solid
Melting Point 137-139°C
Mol. Weight 385.5
Storage -20°C Freezer
Solubility DMSO (Slightly), Methanol (Slightly)
Stability
Category Chiral Reagents, Inhibitors, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point
Applications (-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer.
Dangerous Goods Info NA
References Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),
Extra Notes
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(-)-Actinonin
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1mg
2mg
5mg
10mg
25mg
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