Product Name |
(-)-Actinonin
|
Product Code |
A00002662
|
Chemical name |
(-)-Actinonin
|
Synonyms |
(2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide; Actinonine; 3-[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic Acid; Actinonin; CONA 57; Ro 06-1467;
|
Impurity |
|
CAS Number |
13434-13-4
|
Alternate CAS # |
NA
|
Molecular form |
C₁₉H₃₅N₃O₅
|
Appearance |
Off-White to Light Beige Solid
|
Melting Point |
137-139°C
|
Mol. Weight |
385.5
|
Storage |
-20°C Freezer
|
Solubility |
DMSO (Slightly), Methanol (Slightly)
|
Stability |
|
Category |
Chiral Reagents, Inhibitors, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
|
Boiling Point |
|
Applications |
(-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer.
|
Dangerous Goods Info |
NA
|
References |
Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),
|
Extra Notes |
|
Documents (MSDS) |
Download Document
|
Keywords |
Buy 13434-13-4 | Purchase 13434-13-4 | Order 13434-13-4 | 13434-13-4 supplier | 13434-13-4 manufacturer | 13434-13-4 distributor | 13434-13-4 cost |